22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. And FrameMaker is still a niche product. My experience is very typical. In-patient use. Always be self aware when using fluvoxamine. Server IP cope with resolved: Yes Http reaction code: 200 Response time: 0.27 sec. This is a more comprehensive look at the key evidence supporting fluvoxamine: Hear from the doctors who did the studies directly as well as the Dean of Medicine at Emory University: List of the best evidence-based COVID treatment options. It does not matter how many lives will be saved. Mar. 1991-1992 to 7.1% in 2001-2002. Every year, we pick the 10 technologies that matter the most right now. He is very smart, and he knows that he is very smart, and hesometimes he behaves like he thinks hes the smartest guy in the room, whether he is or isnt, he told me. 36m "We found Fauci was the most highly compensated federal employee. Doing something is better than nothing. Their willingness to lie did. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. This looks ominous, but it harmless. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. One of the drugs, Fluvoxamine, showed a 30 . NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. February 17, 2021. . Some countries dont have fluvoxamine so this is the alternative. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. . skirsch.io Steve Kirsch Home page. These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. has tons of info on fluvoxamine with all the links. He pushes fluvoxamine, an anti-depression drug which despite doing very well in covid treatment studies has been strangely neglected. At that dose, no side effects were reported for his patients (I know of only one person who had mild nausea at that dose) and everyone reversed out their symptoms in an average of 3 days. The evidence is solid. Links to evidence about fluvoxamine including the public data repository. The rest of the board soon followed. One is to reduce the threat of nuclear war. upcoming events, and more. Some speaker, off camera, went on a . No one has been able to come up with an example where phase 2 + this level of evidence resulted in a failure of Phase 3. Note that a total of 77 people got the drug, not 65. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. Several former members told me he began relentlessly pressuring them to promote the drug in media stories, often during exhausting, circuitous conversations. But fear of trying something new prevents any doctor from giving this drug a try. There were no studies reported out so far where fluvoxamine made things worse or neutral. At the dosing for COVID (50mg BID x 14 days), there is a 1% chance of mild-nausea and because the dose is so low and the time it is taken is so short, and there are no psychotropic effects (which require more than 3 weeks of use; the psychotropic effects non-existent if you don't have depression or an anxiety disorder in the first place). The NIH never did a risk benefit analysis of this drug. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. I was just getting tired, he said, before asking to speak off the record. Long haul. Get your prescription in advance of getting COVID. When was the last time you saw a phase 3 fail where there was a 100% effect size in both an RCT and RWE study along with 4 independent observational trials all showing a positive effect, and there is clear mechanism of action where there is less than a 1% chance that it is not working (the SSRI's ordered their impact based on their Sigma activation which is 1 in 120 options), and where in every single case we are aware of the patient taking the drug reversed to normal in an average of 3 days? We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. 90,000 people don't have to die in the next 3 weeks. . According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19). . Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. Another is to identify an asteroid that is going to hit the planet.. Although there is evidence that fluvoxamine can prevent clinical worsening and the need for hospitalizations in outpatients with early covid-19, I have seen no good evidence that fluvoxamine is useful as a substitute for the vaccines, co-investigator Angela Reiersen wrote to me. 4000fluvoxamine750 Steven Todd Kirsch is an American entrepreneur. In short, a lot of mumbo jumbo. Article about the rejection (Stat News) Article about the fluvoxamine rejection (The Verge) NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). The next major effect is that that fluvoxamine activates the sigma-1 receptor. He started a covid-19 vaccine company. 47).. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. What happens when your prescription drug becomes the center of covid misinformation. You can help by bringing this document to your doctor's attention. That receptor also helps regulate the body's . CETF Founder Steve Kirsch discusses why we can't wait for a COVID-19 vaccine, the importance of researching existing drugs now, and our work to raise funds for outpatient trials to identify effective . If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. Last Checked: 03/02/2023. An approach that promised to democratize design may have done the opposite. Those who know Kirsch say this is a typical tactic. It has enrolled only 130 people in the first month and is enrolling only 70 per week now. There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). Boulware disputes that, and says that although Kirschs funding was important, his statements about drugs and vaccines have proven problematic. He says that Facebook took down one of his posts announcing his appearance on 60 Minutes. Lack of action. This is what the Seftel trial at Golden Gate fields used. . To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. Avoid caffeine, benadryl, tylenol, and alcohol. NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). The other doctors aren't using it either because they don't know about it or fear doing anything not approved by the CDC for treating COVID. Adverse reactions/side effects. You can use fluoxetine as well (aka Prozac). Server IP address resolved: Yes Http response code: 200 Response time: 0.27 sec. I think so. 707. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? . Telling the truth, he tweeted. His latest startup, M10, is a spin-off of a spin-off that sells a blockchain for banks. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes, This site requires JavaScript to run correctly. This advice is now outdated. By March 2020, hed settled on the idea of searching for covid treatments in the pre-existing pharmacopeia. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. My publicly shared concerns regarding the safety of the COVID-19 vaccines may have had a negative impact on my company, M10. CETF founder Steve Kirsch accepted an invitation to discuss the findings on a weekly . Part of TV News Archive. Still, in the moment, his question threw me, and I stuttered. His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. . I've collected fluvoxamine evidence here for convenient access. Compulsive fiddling with your mask? Once the Phase 2 result came out, it should have been embraced by doctors. When you need to characterize me, you need to say that Steve Kirsch doesnt go with majority votes on interpreting data, he told me when I asked about his views on ivermectin, which he insists is a silver bullet against covid. He may not be a good scientist, but hes smart, says WVUs Feinberg. Online Status. The paramedics will think you are on drugs. I also think it makes a lot of sense to look for pre-existing drugs that can help treat covid symptoms. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. More recently, hes adopted extremist positions on covid vaccines, which he alleges are toxic. He has claimed that one in 1,000 people who have received mRNA vaccines have died as a result, and even claimed the vaccines kill more people than they save at an FDA public forum, which was first reported by the Daily Beast. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. A very short op-ed arguing for using fluvoxamine against COVID. He was recently featured on 60 Minutes, . Another CETF grant, though, yielded far more exciting results. David Boulware, a researcher at the University of Minnesota, received $125,000 to test the drug against covid. Get your prescription in advance of getting COVID. Hes probably the closest thing Kirsch has to a nemesis, regularly disputing his assertions in blog posts and private email exchanges with Kirsch and his friends. Medicine today isnt about saving your life. He started a new pseudonymous account, @VaccineTruth2, to continue broadcasting messages. I have all of these on hand and I load up on vitamin D3 every day. Vaccine waitlist Dr. B collected data from millions. customer-service@technologyreview.com with a list of newsletters youd like to receive. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. Reason is the hospital gets release from liability if they follow NIH guidelines. Hes spending his own money to do what he thinks is right. YouTube , , , fluvoxamine, , , , , , , , , , Thanks to the volumes of data and information provided by pharmaceutical companies and regulators, as well as large numbers of trials from independently funded research groups around the world, I now trust that theyre safe for the vast majority of adults. The web value rate of skirsch.io is 2 . Fluoxetine is just as effective. Three of the four outpatient trials have been reported out: all were successful. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital security (OneID), or e-commerce (Propel Software). The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. We should not wait for the Phase 3 RCT. That study was featured on 60 Minutes. Read More fluvoxamine The Fluvoxamine FAQ We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. In June, after CETFs advisory board resigned, Kirsch did a Facebook Live video with Zelenko and celebrity rehab coach Dr. Drew. Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. Most doctors wont use it until NIH greenlights it, no matter what the science says. In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. 33. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. Then he hosted a superspreader event. $1M reward: Do we need more data re: Fluvoxamine for COVID-19? How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. Do they sell it anywhere? This post was written to memorialize the corruption. Here are my answers. Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. No long haul symptoms if you start the drug ASAP after first symptoms. . When the pandemic started, he created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs including fluvoxamine which reduces death from COVID by a factor of 12. Steve Kirsch reported that doctors commonly say (of fluvoxamine), "This is the most powerful drug in my arsenal. People are dying. But a panel of key opinion leaders from the NIH, CDC . It is very important to educate doctors because most people rely on their doctors for advice. Independent appraisal committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes. Fluvoxamine is also an . Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to. In other cases, stop cold turkey. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? and increased heart rate (which could be nerves about the dilated pupils). It cant be more clear than this. There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. The CDC has advised everyone to wear a mask. Be warned!. . He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. And that is what has allowed Kirsch, and people like him, to become so influential. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 1.15K 'This Has Cost Millions of Lives': Steve Kirsch on Suppression of Repurposed Drugs and a Spike in Deaths 5 Months After Vaccine Rollout American Thought Leaders AMERICAN THOUGHT LEADERS JAN JEKIELEK Show more Loading comments. MD, MPH; Steven C. Marcus, PhD. Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). The 5 observational studies is icing on the cake. But the potential upsides. In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. To date, the #1 drug with the most evidence to make a significant difference, without any doubt, is fluvoxamine. That way you can start immediately. Doctors who are most familiar with the drug would prescribe it to their patients. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. We are ignoring the advice of the KOL group and doing nothing. Indeed, some of the most prominent people spreading misinformation about ivermectin and vaccines today began by promoting hydroxychloroquineincluding by claiming to debunk Boulwares data analysis. In September, he resigned as CEO and gave up his board seat. P-value was 10^-14 on that study (done by Dr. Seftel). It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for the KOL meeting notes to be published because they were rejected by 10 journals. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. He has made millions from these projects, even if they have not turned him into a household name. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. Mr. Steve Kirsch - A philanthropist and former Silicon Valley tech executive. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli.